Journal of Medicinal Chemistry
Volume 40, Issue 4 (February 14, 1997)
Copyright © 1997 American Chemical Society

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391-394

Neuritogenic Effect of Epolactaene Derivatives on Human Neuroblastoma Cells Which Lack High-Affinity Nerve Growth Factor Receptors Hideaki Kakeya, Chizuko Onozawa, Masakazu Sato, Koshi Arai, and Hiroyuki Osada [Full Article - PDF]

395-407

Novel Naphthalene Derivatives as Inhibitors of Human Immunoglobulin E Antibody Production Masaichi Hasegawa, Kazuya Takenouchi, Katsushi Takahashi, Takahiro Takeuchi, Keiji Komoriya, Yasuhide Uejima, and Takashi Kamimura [Full Article - PDF]

408-412

Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds Libor Havlíek, Jan Hanu, Jaroslav Vesel, Sophie Leclerc, Laurent Meijer, Gordon Shaw, and Miroslav Strnad [Full Article - PDF]

413-426

Tyrosine Kinase Inhibitors. 6. Structure-Activity Relationships among N- and 3-Substituted 2,2'-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners H. D. Hollis Showalter, Anthony D. Sercel, Boguslawa M. Leja, Craig D. Wolfangel, Linda A. Ambroso, William L. Elliott, David W. Fry, Alan J. Kraker, Curtis T. Howard, Gina H. Lu, Charles W. Moore, James M. Nelson, Bill J. Roberts, Patrick W. Vincent, William A. Denny, and Andrew M. Thompson [Full Article - PDF]

427-436

Antiulcer Agents. 6. Analysis of the in Vitro Biochemical and in Vivo Gastric Antisecretory Activity of Substituted Imidazo[1,2-a]pyridines and Related Analogues Using Comparative Molecular Field Analysis and Hypothetical Active Site Lattice Methodologies James J. Kaminski and Arthur M. Doweyko [Full Article - PDF]

437-448

Synthesis, Antimalarial Activity, and Molecular Modeling of Tebuquine Analogues Paul M. O'Neill, David J. Willock, Shaun R. Hawley, Patrick G. Bray, Richard C. Storr, Stephen A. Ward, and B. Kevin Park [Full Article - PDF]

449-454

Chromophore-Modified Bis-Naphthalimides: Synthesis and Antitumor Activity of Bis-Dibenz[de,h]isoquinoline-1,3-diones M. F. Braña, J. M. Castellano, D. Perron, C. Maher, D. Conlon, P. F. Bousquet, J. George, X.-D. Qian, and S. P. Robinson [Full Article - PDF]

455-462

Studies on Selectin Blockers. 4. Structure-Function Relationships of Sulfated Sialyl Lewis X Hexasaccharide Ceramides toward E-, P-, and L-Selectin Binding Kohichiro Yoshino, Hiroshi Ohmoto, Noriko Kondo, Hideki Tsujishita, Yasuyuki Hiramatsu, Yoshimasa Inoue, and Hirosato Kondo , Hideharu Ishida, Makoto Kiso, and Akira Hasegawa [Full Article - PDF]

463-469

Water Soluble Furoxan Derivatives as NO Prodrugs Giovanni Sorba, Claudio Medana, Roberta Fruttero, Clara Cena, Antonella Di Stilo, Ubaldina Galli, and Alberto Gasco [Full Article - PDF]

470-478

Synthesis and Dihydrofolate Reductase Inhibitory Activities of 2,4-Diamino-5-deaza and 2,4-Diamino-5,10-dideaza Lipophilic Antifolates Aleem Gangjee, Rajesh Devraj, and Sherry F. Queener [Full Article - PDF]

479-485

Synthesis and Biological Evaluation of Nonclassical 2,4-Diamino-5-methylpyrido[2,3-d]pyrimidines with Novel Side Chain Substituents as Potential Inhibitors of Dihydrofolate Reductases Aleem Gangjee, Anil Vasudevan, and Sherry F. Queener [Full Article - PDF]

486-494

Novel 3'-C/N-Substituted 2',3'--D-Dideoxynucleosides as Potential Chemotherapeutic Agents. 1. Thymidine Derivatives: Synthesis, Structure, and Broad Spectrum Antiviral Properties Ivan I. Fedorov, Ema M. Kazmina, Galina V. Gurskaya, Maxim V. Jasko, Valery E. Zavodnic, Jan Balzarini, Erik De Clercq, Abdesslem Faraj, Jean-Pierre Sommadossi, Jean-Louis Imbach, and Gilles Gosselin [Full Article - PDF]

495-505

Ortho-Substituted Benzofused Macrocyclic Lactams as Zinc Metalloprotease Inhibitors Gary M. Ksander, Reynalda de Jesus, Andrew Yuan, R. D. Ghai, A. Trapani, Colin McMartin, and Regine Bohacek [Full Article - PDF]

506-514

Meta-Substituted Benzofused Macrocyclic Lactams as Zinc Metalloprotease Inhibitors Gary M. Ksander, Reynalda de Jesus, Andrew Yuan, Raj D. Ghai, Colin McMartin, and Regine Bohacek [Full Article - PDF]

515-519

Cytotoxicity of Platinum(II) Dinuclear Complexes with 1-Alkylthymine Ligands against Mouse Sarcoma 180 Cells Petri Rekonen, Yukifumi Dohta, Masato Kodaka, Tomoko Okada, Ken-ichi Okamoto, and Hiroaki Okuno [Full Article - PDF]

520-527

AMPA Receptor Agonists: Synthesis, Protolytic Properties, and Pharmacology of 3-Isothiazolol Bioisosteres of Glutamic Acid Lisa Matzen, Anne Engesgaard, Bjarke Ebert, Michael Didriksen, Bente Frlund, Povl Krogsgaard-Larsen, and Jerzy W. Jaroszewski [Full Article - PDF]

528-537

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties James A. Monn, Matthew J. Valli, Steven M. Massey, Rebecca A. Wright, Craig R. Salhoff, Bryan G. Johnson, Trevor Howe, Charles A. Alt, Gary A. Rhodes, Roger L. Robey, Kelly R. Griffey, Joseph P. Tizzano, Mary J. Kallman, David R. Helton, and Darryle D. Schoepp [Full Article - PDF]

538-546

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome Charles H. Mitch, Thomas J. Brown, Frank P. Bymaster, David O. Calligaro, Donna Dieckman, Leander Merrit, Steven C. Peters, Steven J. Quimby, Harlan E. Shannon, Lisa A. Shipley, John S. Ward, Kristian Hansen, Preben H. Olesen, Per Sauerberg, Malcolm J. Sheardown, Michael D. B. Swedberg, Peter Suzdak, and Beverley Greenwood [Full Article - PDF]

547-558

Synthesis and Structure-Activity Relationship of a New Series of Potent AT1 Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl-4-ylmethyl)pyrazoles Carmen Almansa, Luis A. Gómez, Fernando L. Cavalcanti, Alberto F. de Arriba, Julián García-Rafanell, and Javier Forn [Full Article - PDF]

559-573

5-Aminocoumarans: Dual Inhibitors of Lipid Peroxidation and Dopamine Release with Protective Effects against Central Nervous System Trauma and Ischemia Shigenori Ohkawa, Kohji Fukatsu, Shokyo Miki, Tadatoshi Hashimoto, Junko Sakamoto, Takayuki Doi, Yasuo Nagai, and Tetsuya Aono [Full Article - PDF]

574-585

[[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone Derivatives as High-Affinity, Selective 5-HT1A Receptor Ligands Maria Modica, Maria Santagati, Filippo Russo, Luca Parotti, Luca De Gioia, Carlo Selvaggini, Mario Salmona, and Tiziana Mennini [Full Article - PDF]

586-593

New 2-Piperazinylbenzimidazole Derivatives as 5-HT3 Antagonists. Synthesis and Pharmacological Evaluation Aurelio Orjales, Ramón Mosquera, Luis Labeaga, and Rosa Rodes [Full Article - PDF]

594-601

Conformational Analysis of Three NK1 Tripeptide Antagonists: A Proton Nuclear Magnetic Resonance Study Giuseppe Caliendo, Paolo Grieco, Elisa Perissutti, Vincenzo Santagada, Gabriella Saviano, Teodorico Tancredi, and Piero A. Temussi [Full Article - PDF]

602-607

Effects of log P and Phenyl Ring Conformation on the Binding of 5-Phenylhydantoins to the Voltage-Dependent Sodium Channel Milton L. Brown, George B. Brown, and Wayne J. Brouillette [Full Article - PDF]

608-621

New Esters of 4-Amino-5-chloro-2-methoxybenzoic Acid as Potent Agonists and Antagonists for 5-HT4 Receptors Donglai Yang, Jean-Louis Soulier, Sames Sicsic, Monique Mathé-Allainmat, Béatrice Brémont, Tiziano Croci, Rosanna Cardamone, Giulio Aureggi, and Michel Langlois [Full Article - PDF]

622-624

(+)-7-Deaza-5'-noraristeromycin as an Anti-Trypanosomal Agent Katherine L. Seley and Stewart W. Schneller , Donna Rattendi and Cyrus J. Bacchi [Full Article - PDF]

625-629

Synthesis and Anti-Trypanosomal Activity of Various 8-Aza-7-deaza-5'-noraristeromycin Derivatives Katherine L. Seley and Stewart W. Schneller , Donna Rattendi, Schennella Lane, and Cyrus J. Bacchi [Full Article - PDF]

630-630

Bioorganic Chemistry: Nucleic Acids Edited by Sidney M. Hecht. Oxford University Press, New York. 1996. viii + 500 pp. 17 × 24 cm. ISBN 0-19-508467-5. $59.95. Manfred E. Wolff [Full Article - PDF]

630-631

Regulatory Protein Modification. Techniques and Protocols. Neuromethods. 30 Edited by Hugh C. Hemmings, Jr. The Humana Press, Totowa, NJ. 1997. xiv + 445 pp. 16 × 23.5 cm. ISBN 0-89603-415-1. $75.00. Staff [Full Article - PDF]

631-631

Bioconjugate Techniques By Greg T. Hermanson. Academic Press, San Diego, CA. 1996. xxiii + 785 pp. 18 × 26 cm. ISBN 0-12-342335-X. $99.00. $49.95 (pbk). Joseph G. Cannon [Full Article - PDF]

631-631

Annual Reports in Medicinal Chemistry. Volume 31 Editor-in-Chief: James A. Bristol. Academic Press, Inc., A Division of Harcourt Brace & Co., San Diego, CA. 1996. xi + 413 pp. 17 × 25 cm. ISBN 0-12-040531-8. $70.00 (pbk). Staff [Full Article - PDF]

632-632

Aleem Gangjee, Farahnaz Mavandadi, Roy L. Kisliuk, John J. McGuire, and Sherry F. Queener [Full Article - PDF]